Advanced Joint, Cartilage, and Even Mood Support. Pinnacle SAMe JointPlex is beneficial in joint health and produces a mood enhancing benefit. Give your joints and cartilage the support they need with same jointplex. -------------------------------------------------------------------------------- Advanced Joint, Cartilage, and Even Mood Support S-adenosyl-L-methionine (SAMe) is a natural molecule synthesized from the amino acid methionine in the presence of magnesium and adenosine triphosphate (ATP). The SAMe molecule is a carrier of methyl groups, and provides a sulfur molecule as well. The liver is a site of methylation and sulfation reactions necessary for detoxification, and can use SAMe to assist in these processes. As a matter of fact, SAMe supplementation has proven beneficial in liver health. SAMe has also been beneficial in joint health. Furthermore, in the brain, SAMe is necessary for methylation of neurotransmitters, and appears to provide a mood enhancing benefit. The tosylate form of SAMe is used in this product. This is preferred since it is the tosylate form of SAMe that has been used in research, and which has yielded positive results. In addition, SAMe JointPlex provides glucosamine and chondroitin sulfates, and MSM which may afford the body the maximum opportunity to support healthy joints. The antioxidant properties of SAMe may help reduce joint damage, thereby maximizing the net support effect of the sulfates and MSM.